Search This Blog

Tuesday, March 31, 2015

Potential for new Lyme therapy: bursting the bubble.

A say the problem with Lyme is “6 old men”. I say this somewhat metaphorically. But a small group of older academic physicians developed a paradigm years ago and has continued to successfully convince the faithful. 

A current patient has been admitted to multiple hospitals. This suffering teenage female suffers with severe neurological signs and symptoms. I had the opportunity to speak with one of her hospital doctors, trained in both infectious diseases and immunology. He asked me why I thought the IDSA guidelines were wrong. He let me speak and he was a good listener as I waxed eloquently (or so I thought). At the end of my well-crafted diatribe he was entirely unconvinced. My patient, a young woman, suffering in the most horrific way has been bandied about from one hospital to the next. It seems each institution is more eager to get rid of her than the last. At the last hospital her mother was told, there are some patients that never get diagnosed. Lyme had well been treated with more than a month of Rocephin. It was something other than Lyme. Why do I think the IDSA is wrong?  The patient’s mother was challenged with same question and she gave her best lay explanation. When Mom read “Cure Unkown” she had an “Ah ha” moment and realized the disease is political and has now learned to save her breath. The IDSA is wrong because of history, politics and a paradigm war. Perhaps there has been a debate about the "science" as is oft said. I think the answer to this question can only really be explained contextually.

It is so brutally unfair that anguished parents fighting for their critically ill daughter are asked to take part in this fight.

This article published in the NYTs is very instructive in this regard. 

Stalking Dr. Steere Over Lyme Disease, By DAVID GRANN Published:   June 17, 2001

Although this piece was written 14 years ago, nothing, or very little has changed. Dr. Steere, a once virtuoso violinist whose career was cut short by a finger injury turned his focus to medicine. By serendipity Lyme fell into his lap and he has been a Moses of the field for the last 40 years. Comtempory medicine has no experience with a multisystem disease such as Lyme disease. The specialization of American medicine makes it more difficult for physicians to see recurring patterns of the disease. Patients instead are diagnosed with psychosomatic disease, fibromyalgia or chronic fatigue syndrome. It is fascinating that Dr. Steere says that chronic Lyme has become a garbage can diagnosis and that fibromyalgia is frequently the real answer.   Dr Steere tells the reporter: “there is no controversy amongst scientist.” The 6 old men and their cohorts live in a bubble, have lunch with each other and validate their beliefs: Lyme is easily treated with short courses of antibiotics. Their influence continues to have far reaching consequences leading to devastation for so many Lyme patients.

Personal attacks, such as in the case of Dr. Steere, have an effect opposite of that desired. The besieged only become defensive, clinging more tenaciously than before to their flawed system of belief.

Science is the best weapon we have. It is finally catching up.

Fourteen years later after this interview, when nothing seems to have changed, a study published a few days ago in PLOS one by Auwaerter, (Feng, Zhang) a stalwart “Steerite” leading the charge in the Lyme war against the Burrasconites, firmly contradicts the basis of the Steere hypothesis. 

In this study the Hopkins’ group admits the cause of ‘Post-Lyme” is uncertain. The idea that Lyme bacteria persist after 2-4 weeks of amoxicillin is “controversial” according to the authors of the study, who then proceed to provide clear, concise and convincing evidence that Borrelia burgdorferi, the Lyme agent,cannot in any world, possibly be killed by this recommended therapy.
The evidence is clear, there is no single drug is capable of eliminating Lyme persisters in mice, dogs, primates and humans -- or in a test tube.  There is no known combination of two drugs that can eliminate Lyme persisters.The authors have discovered a single combination of three drugs: daptomycin + cefoperazone + doxycycline  processing the unique ability to eliminate Lyme persisters in a test tube. This is a huge step forward. 

We may not be able to readily adopt this study for clinical purposes. Daptomycin is an extremely expensive drug and is currently reserved for the sickest hospitalized patients. Infectious disease physician's "stewardship" over antibiotics will likely be a roadblock against the use of this potent drug, and, third party payers, hiding behind the banner of FDA approval will likely not pay for it.  Cefoperazone I have tried to prescribe; pharmacists have told me it is not available.

Only a veritable nuclear bomb of antibiotics could kill all the Lyme in a test tube. Still, Dr. Auewater (at his other job), along with the coterie of Steerites  will continue to tell us the pea shooter therapy is all our patients should ever need. 

The young woman described above, in a wheelchair, delirious half the time, in incredible pain, diaphoretic, with apnea and with constant “pseudoseizures and lapses of consciousness whose blood tests show serological evidence of Lyme, Babesia and Anaplasmosis cannot be helped by science, only by the art of medicine based on years of learning and experience. The Steere camp has no answers but is quick to judge.

The nuclear option, if available, would have to used for care. For example, the patient above has severe Herxheimer reactions with low dose minocycline. Medicine will remain an art as well as a science for the foreseeable future.

New research at the test tube level with drugs such as Claritin and the "nuclear option" may prove to be helpful. Test tube science does not always translate into clinical cures but may certainly provide key, new evidence.

The study gives us another rock to throw at the edifice of the Steere - IDSA - CDC dogma.  It remains a David vs Goliath battle. For now, Lyme remains a political disease. We know the science, which are adversaries claim to hide behind, will prevail in the end.



Kurt said...

You mention Claritin that a typo?

Arachnomama said...

No, there was a big study done showing that claritin could eradicate it but it had to be in ridiculously high doses in no way safe for human beings. Taking claritin won't do any good, and if you took enough to kill the bacteria you would probably die from an overdose. But its an interesting observation and maybe there's some useful info in the study.

Val said...

Four weeks of treatment makes me laugh. Does IDSA ever address the situation where Lyme is allowed to percolate for 25 years before treatment? I spent 26 months on Rocephin IV along with other meds. I'm quite well now but I gave up 30 years of my life because that first doc who said, "I think you have Lyme," never treated me.

Unknown said...

Well, if we could just get away from the drug approach we might make some headway. In July of 2017 I came down with a very serious illness that the plethora of lab tests could not diagnose. I do believe I came close to death. I did not go to hospital because of my severe inflammatory response to certain types of mould and my allergic reactions to many substances; when you become a patient (prisoner) of the allopathic medical system, you really can be in danger if you are someone like myself. It was a situation of get through it or not, basically, at home. I did get through it and still have no idea what it was, but I also never fully recovered. I refused experimental drug treatment because they were wanting to fire in the dark at an unseen object.

So, since I own a powerful Rife machine that is atypical of those out there (meaning it is not a toy and uses a huge capacitive field that has a continuously operating (not sequenced, not specified frequency) range from 100 to 5000 Hz,) I decided to see if I had a Herxheimer ("herx") reaction to it. At extremely low voltage and exposure time I had an outstanding herx. Since herx is diagnostic of the fact that something is releasing toxins, I knew that patience was my best friend and to just get to it.

If you do not know what a Rife machine is, the theory can be found by researching Royal Rife, who applied the concept of using resonant frequency to disrupt organisms to the point of either death or weakness such that the immune system could finish the job. There is a list of what frequencies disrupt what organisms known as the consolidated annotated frequency list (CAFL.) You can also research that if you are interested.

Six months later I am finally able to expose myself to 8 seconds at ten volts; it took me a really long time to reach that level, having had to start at 5 volts and about 1/2 second to not be "herxed into oblivion" by the exposure. I will add that it is part of the philosophy of using ANYTHING that kills pathogens: herx is a sign that the detox system is overloaded. You do NOT want to induce extreme herx because it's just stupid. You treat at the level where the sufferer is not disabled by the herx, and as the pathogenic load goes down, treatment can escalate at pace to keep herx barely detectible. This is why patience is a requirement for success.

As far as I know, spirochetes cannot hide from electromagnetic fields by changing form. That is why a Rife machine that actually works is effective. If the field is large enough, the entire body is exposed at once, and a person does not have to turn the noun "coil" into a verb, "coiling" here and there and never, ever reaching the entire body at once, hence always missing part of the problem and never achieving a cure.

Since with my machine, exposure for 20 minutes at 20 volts is deemed "you have killed all you can with this device," I clearly have a long way to go. Meanwhile I no longer have to use the handicap parking and am back playing the oboe. I still can't walk around the block but am happy to be able to walk around in the grocery. Three weeks of doxycycline done as an experiment resulted in nothing beyond wrecking my intestinal microbiome. An effective (once again, most are toys) Rife machine is the opposite of the silver bullet approach; you don't even have to know what you have in order to fix it, because, stating once again, herx is diagnostic.

I am an engineer and was taught to think in the way engineers think. Doctors are not taught to think like engineers, and that is why those old guys are stuck where they are. It is also why the entire Western medical system is stuck where it is; silver bullets are part of a "use this to kill that" when the "that" has to be known in order to know what "this" to use. They keep spending all the money trying to find more and better silver bullets, most aimed at symptoms instead of causes. And we are where we are.

John kim said...

How can I explain this to the world that there is a man who can cure HERPES, I was diagnosed for the past 1 year I have being into HERPES since 1 year, so I decide to look for help in the internet then I found a post write about this great man called DR. Yakubu , people say good thing about him that this man have cured, a lot of people in the internet, him has power's to cure HSV1 AND HSV2 I don’t believe that there is a cure for Herpes Simplex Virus because though there is no cure for herpes that what I have in mind HERPES had no cure well , my HERPES is negative through the using of herbal cured of DR yakubu , I contacted this man for help because of what i see in the internet. if you need his cured just email him now on , thank you DR. i will never stop shearing you testimony DR. Yakubu . him Can as well CURE THE FOLLOWING DISEASE:-1, HIV/AIDS, 2, Diseases of the hear 3, Malignant tumors 4. Cardiovascular diseases 5. Diabetes mellifluous 6.Influenza and pneumonia 7.Alzheimer's disease 8. hsv1 - hsv2. If you need LOVE SPELL. E.T.C contact him or you whatsapp him on +2348057353647...
Dr.yakubu 하나님은 내 삶을 회복시켜 주신 것에 대한 축복을 계속할 것입니다. 나는 사람들에게 증거를 계속 나눌 것입니다.

Amelia Bethany said...

Before people said there is no cure for herpes virus but today many people have now believe that there is a cure, herpes virus can be cured through Africans roots and herbs, Dr.chala he is the one of the great herbal doctor in Africa and he has the cure on this virus last month he share his herbal medicine in some medical hospital and now he is well recognize as one of the best in Africa, you don’t have to be sad any more or share your tears any more on this virus when the cure have already be find by Dr.Chala email him on or https:// or