Tuesday, October 3, 2017

Lyme: new and emerging directions for research and treatment

Treating (chronic – complex) Lyme is not a cake walk. Patients are looking for the holy grail.  Caveat emptor - Let the buyer beware.  If it sounds too good to be true it probably is.  Many patients are paying huge sums of money for therapies that are ineffective and unproved, at best.  It is also hard for many patients to place in proper perspective scientific research papers.
A recent study used “high-throughpoint” screening, searching for new drugs for Lyme.  The researchers considered killing both growing spirochete and persister variants.  Some of the most effective agents are chemotherapy drugs.  These drugs are toxic and dangerous. I think taking these drugs for Lyme is unwise.  Many cephalosporins were found useful.  Interestingly, some first-generation drugs work. I was under the incorrect assumption that only second and third generation cephalosporins were effective.  Most of the drugs are IV, administered 4-6 times per day.  Azlocillin sounds promising but is not available in US.  Eyrthomycin is said to be effective – no true in my experience. Zyvox is said to be highly effective. This I believe. It is available orally and IV.  Its price is prohibitive. This a very big gun, used to treat multidrug resistant bacteria. Not first line therapy.  The quinolone Avelox worked very well, inhibiting stationary and growing forms of Lyme. The study suggests that Avelox does it all.  Quinolones are potentially toxic and can cause tendon ruptures. Currently this class is not first line therapy. 
Then there is Antabuse?  Some recovering alcoholics take it daily.  If the patient slips up and takes a drink, the drug induces severe vomiting.  It is generally safe and well tolerated, requiring some lab monitoring. It may has potential as a therapy but is completely untested, even in a mouse.  Currently this is not a recommended therapy.
The cephalosporin Claforan which was extremely effective, 99.9% killing in a test tube.  It may surpass its competitor Rocephin.  The drawback is the drug is dosed 4X per day.  Maybe a less cumbersome regimen will be effective. 
Another recent study found something else. The statin drugs, cholesterol lowering drugs decreased the load of Lyme spirochetes (in mice).  The drug inhibits an enzyme needed in the formation of peptidoglycan, an essential component of cell integrity.  The same pathway is found in other pathogenic bacteria, including Staph, Strep and Listeria. 
Should we all go on statins?  Cardiologist think we should.  This begs the question:  is it good or bad for the brain to lower cholesterol?  About 25% of the body’s cholesterol is in the brain.  Cholesterol is an essential component of the thick white, insulating coating covering the axons  (myelin) – the white matter of the brain.  Perhaps lowering cholesterol is bad for the brain.  Studies are conflicted as to whether statin drugs (Lipitor etc.) increase the incidence of dementia/Alzheimer or decreases the risk of dementia/Alzheimer’s.  The current belief is the risk of dementia is less. 
Your neurons are completely myelinated by the teen age years. There is some dynamic remodeling that occurs during adulthood, therefore MRI white spots – damage to myelin may improve over time.  Studies have shown that statins decrease CRP and inflammatory cytokines which may aggravate brain inflammation. Statins may have anti-inflammatory effects in the brain.  After reviewing some literature, I think it is safe to take statins when you have “Lyme brain.”  The drugs reduce spirochete loads in mice. Whether it works in humans will be uncovered in future research which may be decades out. This is not a primary treatment for Lyme disease.

Most patients do not have a scientific background.  Many have learned the hard way.  IV ozone, magic inhalation therapy and stem cell transplant procedures are not going to cure you.  Maybe they help, maybe they don’t. A few of my patients have spent many thousands and tens of thousands of dollars discovering results fall short of the hype.  Treating chronic Lyme, in its worst forms is a process, a marathon, not a sprint.

Another antibiotic touted for chronic Lyme is the anti-Leprosy drug Dapsone.  It may have more toxicity than other choices. 

Anti-tuberculosis are also being promoted.  The TB drug Rifampin is already widely used.  Dr. Horowitz reports success with Pyrazinamide. This is the famous anti-persister drug used in active TB. The drug was tested in mice originally. Test tube screening was omitted in the 1950s at the time of development. When the drug was eventually tried in a test tube it did not work!  Based on screening procedures today, the anti-persister drug would have never been discovered. What else are we missing?  PZA is an indispensable drug for TB.  There is no evidence that it will be effective in Lyme disease. The mechanism of PZA is dependent on an enzyme only known to exist in Mycobacteria (genus of TB).   It has the potential for liver toxicity.

Is there anything new to try?  There is always something new to try.  Let's find what works best for you.


lymie said...

Lots of negatives with the drugs turned up in these searches, which work in petri dishes or test tubes. When they find or invent one that is safer, then I will get excited. It is definitely hard to sit on the sidelines with all the things people are trying, but it is more cost effective and safer. Even if the powers that be admitted it was a persistent infection that defies current treatment for some people, we would still not have a cure. And it might be that research would go faster, but it will not be overnight in my opinion that the holy grail is found.

I have said for years that I was buying time with lyme treatment, but didn't entirely believe it. Some part of me still hoped one day I would be well, that I would outlast the spirochetes. Who was it that said "since I gave up hope, I feel much better?" If I could just give up hope and appreciate the time I have bought, that would be good.

Oriol López Marti said...

Claforan has saved my life... high dose pulsed...from nearly dead to live the life again.... 12gr 3xday 4 days per week and 3 days off... its better than rocephin.