Eva Sapi's recent research calls into question everything we thought we knew about Lyme "cysts." In fact it destroys the old thinking.
We have heard about cell wall antibiotics, intracellular antibiotics and cyst-busters. Think again.
She investigated the effect of various antibiotics on Lyme spirochetes and round body forms - also know as cystic forms.
Doxycycline worked according to plan. Doxy inhibits protein synthesis - it kills bacteria, including Lyme, by action within the cytoplasm, inhibiting the manufacture of proteins required for the bacteria's survival. Doxy and others are commonly referred to as intracellular antibiotics.
Spirochete loads decreased by about 90% while cyst levels increased by 200% - just as expected.
Then amoxicillin data was presented. Amoxicillin inhibits the formation of bacterial cell walls. Amox and similar drugs should then only be effective in killing spirochetes with an intact cell wall. This is where the results start deviating from the plotted course.
Amoxicillin killed 90% of spirochete forms - OK, but -- it also killed 68% of the cystic forms! Amoxicillin and other cell wall drugs are not cyst busters - only specific anti-parasite drugs kill cysts - or so we thought.
Well lets think again for a second: what are cysts? Are they balled up forms of spirochetes with a different kind of membrane - or blebs (also described) expressed through the spirochete membrane? Maybe the former retain much of the cell wall from the original spirochete - maybe that is why amoxicillin works here.
This would seem to clear up a nagging question raised by others. Are cysts and L-forms really the same thing? These results show that cysts cannot represent a version of L-forms or spheroplasts which result when gram negatives shed their cell walls. If this were the case a cell wall drug would be ineffective. Cysts and L-forms are distinct and different forms. (There may be a hole in this reasoning. I will explain later).
OK So we have learned something new: cell wall antibiotics can also kill some cyst forms which are not L-forms.
Let's look at some more data. Tigecyline is a not a cyst drug either. Wrong. Tigecycline kills 90% of spirochetes, good so far, but it also kills 90% of cysts! Tigecycline is an intracellular antibiotic similar to doxycycline! Another fly in the ointment.
OK. Cysts with their lower metabolic rate, still need ribosomal proteins to survive, just not at the levels of intact spirochetes. Tigecyline is a more powerful drug, higher levels are delivered into the cytoplasm of the cysts. This makes sense. Cyst forms are still essentially a pleomorphic version of Lyme bacteria with somewhat different features. In this scenario, cysts could be L-forms. But we have already shown that this is not true because amoxicillin can kill them. Right?
Amoxil is a cell wall drug. I thought so. Kersten, (antimicrobial agents and chemotherapy, May 1995, p. 1127-1133) states that Beta-lactam antibiotics, which include amox, penicillin and Rocephin, have been shown to cause a specific loss of total intracellular RNA in the absence of cell wall hydrolysis. In other words, amoxil could possibly work in part as an intracellular agent. If this is right cyst forms of Lyme could still be L-forms. So perhaps we have not shown that L-forms and cyst forms are different after all.
The question remains unanswered.
Let's get to the Cyst-busters. It takes antiparasitic drugs, so we thought, to kill the cysts. Cyst-busters, anti-parasite drugs, kill parasites (and Lyme cysts) not bacteria. The so called cyst-busters were heretofore used in combination or cycled with other antibiotics. Previous thinking was that typical antibiotics would kill spirochetes and/or L-forms and that cyst busters would disrupt only the cystic forms.
Cyst-busters do not kill intact spirochetes - so we are told. Very wrong this time.
I cannot cover the whole Sapi study. The most exciting finding is that Tindamax (tinidazole) - our premier Cyst-buster, is the most effective drug overall. This "cyst-buster" kills 90% of cysts and spirochetes: by far the best drug. We don't know it's effect on L-forms, but we can guess. Tindamax probably works by an intracellular mechanism. If this is true it should be equally effective against L-forms.
It gets even better. Tindamax is the only drug which does a great job on biofilm colonies as well!
(not to be discussed now). More on biofilms later.
Tindamax passes the blood brain barrier and penetrates well into most tissues. It has been effective in my patients with neurocognitive deficits - neuroborreliosis.
Recently I tried it on another sort of patient. This patient has had intractable Lyme arthritis of his knees. This young athlete had been extensively treated with IV Rocephin followed by a year of typical oral antibiotics. Knee effusions have persisted - until I prescribed Tindamax. Now, after two months, the fluid in his knees has evaporated. His knees are dry and painless for the first time in over one year.
This raises the question: should Tindamax be used as mono-therapy? Well, I cannot endorse blanket use at this time. Tindamax has a black box warning. It has been associated with cancer in some laboratory animals. Perhaps there are more compelling reasons to use Tindamax, but this will have to wait for another post.
My nagging question:
Why does penicillin kill Lyme? It shouldn't. Lyme is a gram negative bacteria. While certain Beta-lactam antibiotics can kill gram negative bacteria, penicillin cannot. Penicillin is only active against gram positive bacteria.
Maybe this other mechanism alluded to above, the alternative intracellular RNA mechanism is significant and explains why penicillin kills Lyme spirochetes. Maybe not.
We need to continually reevaluate things which we have assumed to be true, because many of them are not.
Awesome post. Keep up the good work. Out of all the information out there on lyme, I find your blog to be the most level headed and logical.
I really love this post!!!
Speaking as one of your patients, I must say that when you switched me to Tindamax a few months ago it made all the difference in the world and i'm starting to feel better than I have in years. And I give you full credit for my progress with treating me for chronic lyme disease. Keep up the good work and awesome posts! :)
I went to Dr. Sapi's conference and she also presented combinations and Tindamax with Doxy worked the best.
It was great to see the presentations and while the bacteria load only went down to 10% the duration was not for a long period (I remember 72 hours).
Our daughter was on tindamax for 7 months and it helped tremendously with the neuro symptoms (she is 11 and has Lyme and Babesia) but we stopped due to some adverse reactions (alergic - itching which was triggered when we increased the dossage and anorexia - fortunately after appx. 6 weeks her appetite picked up but we have a ways to go to increase body weight).
One of Dr. Sapi's research students indicated it can take up to 6 weeks for a cyst to break and release spirochetes.
Thank you for the informative post. Son, 12, just started Tindamax and Bactrim. He is sleeping a lot at the moment, but I hope it is a healing sleep! Thank you again for all of your posts!
Great post, Tindamax gives me vertgo and headache, how do you rate Alinia as an alternative?
"Why does penicillin kill Lyme? It shouldn't. Lyme is a gram negative bacteria."
Actually, Lyme Borrelia is neither specifically gram negative bacteria or gram positive. It is in a category of its own.
Notes from my blog:
From the book, "Borrelia:Molecular Biology, Host Interaction and Pathogenesis":
""Although Borrelia spirochetes are often, but mistakenly described as Gram-negative bacteria due to their diderm, i.e. double-membrane envelopes, a closer examination reveals significant differences in composition and architecture. Probably most striking is the lack of LPS, the presence of major surface lipoproteins at the host-pathogen interface during transmission, persistence and ensuing pathogenic processes and the additional function of periplasmic flagella in defining cell shape."
and an additional source:
"Borrelia were thought to be Gram negative because of their double membrane structure, but genetic analysis places them - along with other spirochetes - into a separate eubacterial phylum. Ultrastructural molecular and biochemical studies have emphasized the wide taxonomic gap between spirochetes and Gram-negative bacteria. ( The Genus Borrelia. Melissa Caimano. Prokaryotes (2006) 7:235-293.)"
There is so much that has yet to be understood about this bacteria.
This is so exciting to me as I'm a mother to a 13year daughter who has been on Biaxin & Plaquenil. She has been plagued with nero symptoms.I would love for her to see you and try Tindamax. She is so desperate to get her life back as eveyday is a struggle for her. If we are able to make a appt please email @ email@example.com Our family would be forever greatful
What is the latest research on IV Flagyl? Will it work as well as the others mentioned to kill cysts? Thanks!
I'm very excited about Tindamax but afraid to use it because of the black box warning. My doctor is very sensitive to those so I figure it's for good reason. But people here are using this drug with success. Can you elaborate on the cancer warning?
Did your patient who had the lyme arthritis take Tindamax for the entire two months?
Tindamax is the newest anthelmintic but if you see the studies in vitro showed it as the best cyst buster while the in vivo showed the Flagyl because the doses used in vitro were lower i=of Flagyl equivalence. i just mean to mention this to show there are other anthelmintics that could serve as well, in my particular case Tindamaz didn't do much while Flagyl and ivermectin did much. The point is there are medicines to treat if the concept changes from just treating with antibacterials or antibiotics to anthelmintics or call them antiparasitics, my opinion!
Tindamax has been the first drug in a year to change my life. I am so greatful for it and i think it saved me many years of other antibiotics.
hi i've been on tindemax for several months now and not doing anything but keeping me where i was I am and stagnant in my treatments - at 1st thought it was helping, nope. my llmd switching me to doxy start of new yr bacuse of herx after chritmas - should i indeed stay on the tindemax? been on it 4+ months no improvement? hummmmm. thanks for the article - & i'm surprised i could scan it and get some helpful info. :-) lyme brain
Have you noticed that in her published study in may 2011
Eva Sapi doesnt mention anymore her conclusions about Plaquenil.
Do you think she has moved backward?
hello. All tried, IV ceftriaxone, doxy, metronidazole. Whas the dosis of tinidazole for 60 kg weight? 2*500 kg a day?
Have you tried GcMAF on your patients? This appears to work by rebooting the immune system. I've googled it and there are lots of positive comments out there, but wondered if you could comment and give your point of view? Thanks
Is Alinia as good as tindamax? I wasn't able to use tindamax due to side effects.
Thanks for your help.../
Mistake does not only teach you how to be strong but also hot to stand up again and to do good next time. Visit my site for more information. Have a good day always and thank you for sharing your knowledge and wonderful article to the public. I do hope that you can inspire more readers.
Your description is really very effective which will definitely help the readers who have the disease or problem, that's why I appreciate your blog article. Thanks for sharing it and keep sharing.
Tramadol 100 mg | Amoxicillin 500mg
in your judgment, does tindamax penetrate cancellous and cortical bone very well? I have late stage Lyme and probably bart and babesia and have had nothing but decline and infection now to most bones of head and face. Am nearly convinced this illness is incurable because of pleomorphism and symbiosis with bone and nerve cells. Have you heard good things about ivermectin and lYME? Any ideas if it penetrates into bones?
We all need challenges in our life to keep motivated. I really had a great time scanning and reading your blog site and i was so amazed with your great artwork. I do hope you could inspire more readers. You can also visit my site for some interesting stuff.
there's only one way to avoid chronic lyme disease, and that is get a regimen of antibiotics immediately after the bite, same day, and no later than a week or 2 later. after about 19 days it gets into your spinal and cerebral fluid and is very hard if not impossible to eradicate. it would pay to take along a stash of doxycycline when hiking or camping, in case one gets bit. there's no other way around it. most of the nightmare horror stories about lyme are because it went months or years before being diagnosed. by then the horse has already left the barn. the government doesn't want to admit how bad this is, because they don't want to create "public anxiety"- but in reality they don't want to admit just how f-ing BAD it is. and the medical industry is working along with the insurance companies to not treat people, to save money on meds and treatment. it's as plain as a nose on a face- the longer they can keep telling the big lie, the longer they can save money. this would cost them billions $$ to treat correctly. and many lyme patients would have major lawsuits against their MD's and insurance co's for lack of treatment over the years. if you have an MD who is dragging his feet treating you, tell them you will sue if you get sicker. you'll see how fast they treat you then. take grape seed extract, apple seeds, and oil of oregano to try to kill the cyst forms of lyme.
I already gave up on ever getting cured of HSV2 because I have try many treatment none of them work out for me I have be to different hospital they always tell me same thing there is no cure for herpes when i came across a post about Dr momoh, in the net from a lady called Rebecca I contacted him and he reassured me with his herbal medicine which I took according to the way he instructed, that how i was cured. I doubted at first because I have been to a whole lot of reputable doctors, tried a lot of medicines but none was able to cure me. so I decided to listen to him and he commenced treatment, and under two weeks I was totally free from Herpes. I want to say a very big thank you to DR momoh for what he has done in my life. feel free to leave him a message on email firstname.lastname@example.org and also WhatsApp him +2347083724098.. or visit his website https://drmomohherbaltreatment.wordpress.com. He can still be able to help you with this herbs medicine: 1...ALS CURE/DIABETES CURE/EPILESY/HPV CURE/LUPUS/HEPATITIS/CANCER/GOUT
I WANT TO USE THIS OPPORTUNITY TO SAY A VERY BIG THANK YOU TO Dr Ogberaese, My name is Leonard Shirin i am so happy to share this testimony on how Dr.Ogberaese healed me from genital herpes. i was detected with genital herpes around 10th may 2019, and ever since that day i have been looking for a way to end this virus from my body, but the more i try, the more i was told there was no solution. Few months ago i saw a testimony of some people on how Dr Ogberaese cure them from HERPES VIRUS, i also heard about it on media when a young lady also gave her testimony saying Dr Ogberaese cured her oral herpes. I was left with no other hope than to contact Dr Ogberaese and give him a try. I contacted him and told him what i was going through. He said he could heal me, that he is going to send me a herbal medicine and He sent the medicine as he promised. I took this herbal medicine for 1 week and it was obvious that his medicine was for real, because the herpes started clearing from my body. Later at the 2 week, i went for medical check up and i was surprised when my doctor told me he found no trace of the virus in me again. At first when he told me, i was so shock and still did not believed until he gave me my test result. to make my story short i am now free from herpes, after many months of sorrow and my sickness is gone, i thank God for leading me to this man, and i want to also lead you to him if you have any illness like HIV, HPV, hepatitis B, asthma, cancer, Diabetes, COLD SCORE,TOOTH ACHE FIBROID and AUTISM. You can email him on email@example.com or whats-app him on +2348073818653. visit him on his website: https://dr-ogberaese-herbal-home.jimdosite.com
Powerful Herbal treatment is 100% guarantee for HSV cure, the reason why most people are finding it difficult to cure HSV 1 an 2 is because they believe on medical report, drugs and medical treatments which is not helpful to cure HSV and hasn't proved any sign of helping. Natural roots/herbs are the best remedy which can easily eradicate herpes forever. I never believed it until I was helped and cured of my 16 months genital herpes with natural herbal medicines from Dr oduku. Where other medical prescribed drugs and treatments failed, Dr oduku natural herbs helped saved me from Genital herpes permanently and I’m so grateful for this. You can also get help from this great and powerful Herbalist Dr oduku by reaching him on whatsApp +2348124765093 also EMAIL: firstname.lastname@example.org or visit his page https://www.facebook.com/Droduku/ or his tiktok.com/@drodukuhome
Dr Oduku is the best herbal doctor.
Here is my private e-mail email@example.com you can also get in touch with me.
Post a Comment