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Sunday, February 14, 2010

The IgM question: Is it chronic Lyme disease?


Many patients have been told by their physicians they do not have chronic Lyme disease because Western blot antibodies are in the IgM class, not the IgG class. The doctors themselves may be confused -- or adamant. The adamant ones very likely don't believe chronic Lyme exists. If you, on the other hand, believe chronic Lyme is real, you may want to discount opinions proffered by those who do not share those beliefs.

Lyme acts differently immunologically than many other germs. Patients with only IgM antibodies may have Lyme and or/ chronic Lyme.  In the typical scenario of  antibody response to infection the immune system makes IgM antibodies in early infection and then makes IgG antibodies in late infection. As the amount of IgG increases IgM decreases and then goes away.  This is not always the case. Lyme is a clear exception to this rule.

Peer reviewed medical studies have contributed to the confusion. Selection bias inherent to published studies is one problem.  The only patients selected for NIH sponsored clinical trials have had IgG, not IgM antibodies. One investigator, Brian Fallon, who treats a lot of Lyme patients, found it challenging to find patients with the 5/10 IgG band requirement; less than 5% of his patients fulfilled the study entry requirement. All studies require certain criteria for inclusion in the study. These criteria were used for standardization and in no way suggest or prove that a particular IgG response is needed for the diagnosis.

A large chunk of chronic Lyme patients have only IgM responses. Some have mixed IgM and IgG responses. In some cases IgG responses are favored and in others IgM.

Those from the no-such-thing as chronic Lyme camp stake out the position that persistent IgM responses without later production IgG antibodies represent false positive responses.  Patients with only IgM responses are told that they in fact never had Lyme, or they may be told they have Lyme but it must have a new case.  Science tells us something else. Some patients make only IgM antibodies. And it is known that IgM and/or IgG antibodies may persist for years after acute infection.(Steere). The CDC has not been helpful.  The CDC two tier test, ELISA followed by Western Blot standard was developed for surveillance, not clinical diagnosis. The claim that the test lacks accuracy in early Lyme but is virtually 100% accurate in late stage Lyme is crazy and has no basis in science -- or published evidence. This unfounded statement unfortunately lends credence to the Lyme deniers who push the falsehood that IgM bands equal false positive.

IgeneX has published its finding that 2 specific IgM or IgG are diagnostic of the disease, stage of the illness not withstanding.  Aucott has found that 20% of patients with treated acute Lyme are unable to produce IgG antibodies, likely a genetic variable. Steere published data showing persistence of IgM antibodies in late Lyme in the 1990s. This knowledge is not new.  Existing literature supports the idea that certain Western Blot antibodies are highly specific for Lyme. If specific antibodies are present it is unlikely they are the product of a false positive test, irrespective of antibody class.  When only IgM antibodies appear there is a alternate hypothesis. The persistence of IgM antibodies may suggest the immune system is "chronically" seeing Borrelia as an acute--new infection. This interpretation is applied by doctors in other situations. For example EBV. IgM EBV antibodies are frequently interpreted as evidence of reactivation of the infection.

Antibodies are the result of "humoral" immunity or acquired immunity. The immune system "reads" the pathogenic germ and turns the information over to the body's antibody factory. IgM and IgG antibodies are produced by the same cells: B lymphocytes. These lymphocytes may become plasma cells. The change from IgM to IgG is due to a genetically directed molecular switching mechanism. This class switching--IgM to IgG-- may not occur or occur poorly. We don't know why but these facts have been established by evidence based science.

In my experience, Lyme patients, on average, produce slightly more IgM than IgG antibodies. This may be hard to see since most IgM assays present limited data (few bands). Certain antibodies, for example: 18, 23, 31, 34, 39 41 and 93 are HIGHLY specific for exposure to Lyme bacteria and this is well described in many places.

Doctors known as LLMDs have know for decades that the IgM vs IgG class distinction does not apply to Lyme.

Addendum:  Antibodies are Y shaped molecules/proteins made up of heavy chain and light chains.  Some portions are variable and some portions are invariable.  Binding to antigen occurs when a variable portion at the end of one leg of the Y has a structure reconfigured (controlled by gene modification).  This is the part which is analogous to taking a key to hardware store to have it copied. A generic antibody is like the blank key. The key (specific antibody) is formed through a complex process. The same cells, B lymphocytes/plasma cells that make IgM antibodies also make IgG antibodies. When the class of antibody is changed it is referred to as isotopic switching.  Here is the critical piece of information: the key - the variable portion of the antibody is unchanged when IgM is changed to IgG. Rather an invariant heavy chain is swapped out. Meaning: the specificity of IgM antibodies is identical to the specificity of IgG antibodies. Remember, the immune system is controlled by mediators, cytokines. The switch from one class to the next is controlled by cytokines. IgM antibodies induce cytokines which differ from those of IgG antibodies. This is why IgM and IgG antibodies have different biological properties. The cytokines communicate with different parts of the most complex system (immune system) in the body outside of the brain and the wide array of moving parts are given different tasks. IgM signals are different from IgG signals. It should all work together for the most effective killing of unwanted pathogens. The operative word is should. 

Germs evolve. Germs are smart. If a pathogen can modify the signals and confuse the cells, if gives the highly motivated germ a leg up, a survival advantage, and we know that Lyme infection can modify cytokine responses. Maybe that is why isotopic switching, IgM to IgG fails for many patients. 

Take home point:  the part of the antibody that specifically binds to the antigen is 100% unchanged when IgM antibodies are replaced by IgG counterparts. 

If you suspect you suffer with manifestations of Lyme disease only an experienced knowledgeable doctor can make the diagnosis.

Please see other BLOG posts for more information regarding this issue.




69 comments:

Unknown said...

Excellent blog as usual; keep it up please.
Any thoughts on seronegativity, especially after very prompt use high dose Amoxv? This seems to have totally negated immune response.

Unknown said...

Thank you for your excellent explanation. I have a 16YO daughter who was just diagnosed by her LLMD as having Lyme. Her IgM test came back + from Igenix (even by CDC standards) but IgG was - only having 2 bands. I have been searching the net all weekend trying to find an explanation. The LLMD said the treatment is long and that she'll get sicker before she gets better. Because of the all of the docs who have dismissed us over the past 2 years, I really needed to understand the labs and what they meant to make sure we were on the right course. Thank you I believe we are. Your blog has been very helpful. Seattle Mom!

Michele said...

I believe the information is out there and the IDSA has it. What it will take for them to treat patients with chronic lyme I just don't know.

Information Services Team said...

Thank you for examining this issue. I too had a positive two strata IgM (WBlot) with a negative ELISA and negative IgG. I have just had a infectious disease consultant from THE top London hospital inform me that I do not have Lyme, ignoring both the WBlot and 9 years of clinical symptoms. Thanks for having the guts to help Lyme patients.

Gina said...

Bravo to you!! Thank you for this informative blog. It is very sad how many people are suffering with Lyme disease without treatment.

My daughter and I both have Lyme disease and we are successfully being treated by a wonderful physician.

Thanks again!!

bricily said...

Not that you need verification of your point, but...I tested IgG positive for all 3 bands in Sept 09 and received the CDC "seal of approval" I also had 2 positive IgM bands. I had been sick for 5 years in cycles and I know for certain that I was bit in 2004.
Is there anywhere a patient can volunteer to be part of research? Where we can say- hey, use my info, sign me up! I want my battle with illness to actually battle and improve knowledge! Thanks for the blog,
Treated in Seattle

CMS said...

I was just diagnosed Weds after two years of chronic fatigue, joint pain, rashes, headaches... and was really thinking something was "up" when the Dr told me that IgM was elevated indicating an early infection. I have had these issues for 2 YEARS, that is not early. What is the prognosis for someone diagnosed 2 years into an infection?

Unknown said...

I was just diagnosed had positive Western Blot, IGM positive, but no IGG bands. A traditional doctor told me I do not have cronic lyme because the I have no IGG bands.
I also had the HNK1 CD57 panel result of 27, indicates chronic lyme.

I was bitten about 13 years ago and had multiple bulls eyes rashes, that re-appeared every spring for years. Even with this information the traditional infectious disease doctor does not believe I have chronic lyme. Very frustrating!!

FrenchGirl said...

I've noticed several posts from Seattle. Would love to connect with others who are going through treatment or seeking testing/treatment. Email is French_girl07@live.com. Lynn

Pearl said...

What is the hang up about "chronic Lyme?" Chronic Fatigue Syndrome is defined as having fatigue et.al. for at least 6 months. So if I've had Lyme for at least six months, does that, by definition, mean I have "chronic Lyme?"

I believe I've had Lyme and Bart for 6 years, yet my WB IgM is positive on 18 31, & 41 (positive acc. to IGeneX, negative acc. to CDC), and my WB IgG has only 1 positive band. With over 30 symptoms, I clearly have Lyme. Do I have Lyme or do I have chronic Lyme? Or is "chronic Lyme" only applied to people who resist treatment?

Are doctors looking for an excuse to say, "It's not Lyme"? Why?? Is there some kind of punishment out there for doctors who diagnose Lyme?

LymeMD, Thank you for your rant on "evidence based medicine." Through my recent experience, I have come to the conclusion that most doctors are enslaved to test results, and are uncomfortable and unwilling to make a medical decision without proof. Afraid of being wrong and ridiculed and sued? Perhaps. To me it is proof that they are insecure in their knowledge of Lyme and are unwilling to do the research.

Tt22177 said...

I was have tested positive igm bands 39 and 41 for 8 months now no igg bands. Orginally when i was " diagnosed" by my pcp I was given 3 weeks of anitbotics and went thru feeling like i was dying (vertigo, bells palsy, headches etc). Finally got in to see a ID specialists. Was told it was a false positive test. I shouldve felt better after treatment and all symptoms were " in my head". Now 6 months later still feeling symptoms (fatigue, sore achy muscles,joints, headaches, etc)and pcp is trying to help to best of her ability. Prescribing fibro meds and seeing a chiro. Recently she contacted a ID specialist in Boston who suggested rerun western blot see if igg bands show up. They didnt only igm still. I am at a loss. I know i dont feel well and i know its not in my head. Thanks for posting here makes me feel justified in some way.

Anonymous said...

Hi there...a quick question: I've read there are several different bacteria types that are considered lymes. If this is true, would that explain why some people do not get the EM rash? So possible only some of the lymes bacteria actually cause it? And therefore could this also be why it is hard to detect; the tests are only using one bacteria strain vs using all the strains? I hope this made sense...I'm NO doctor, that's for certain.
Thanks,
Anne

kaney said...

Lyme Disease is not a condition that is easy to diagnose. You should already know that it is spread through tick bites (most of the time). You've probably already heard about the rash in the shape of a bulls eye that happens after a tick bite.

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Unknown said...

By what standard were you confirmed? My 18 year old daughter recently tested positive for lyme with IgM positive. She was treated with 3 Weeks of doxicyclin by our primary doctor while we worked to get her accepted by an infectious disease specialist. We saw him just a few days ago and he immediately stated that the IgM factor indicates a false positive but agreed to test her again. I was initially somewhat relieved but left his office still frustrated because his reasoning was largely based on the fact that we live in Arizona. Another factor is that she also tested positive for herpes simplex IgM but hsv1 & 2 are negative are of great concern to me.

Unknown said...

My IGM test was negative and my IGG was positive. I have had Lyme twice in the past, and my IGG numbers are higher now than with my last bout of Lyme, so I am being treated again, even though It shows I don't have a current infection because my IGM was negative. Does this seem like chronic Lyme?

Dave said...

I'm sitting in a hospital bed right now for 4 days as they run every test possible on me. I was treated in Aug 08 and Feb 12 for lymes and was giving a 30 cycle of doxy pills. The symptoms came back hard with extreme fatigue, facial paral, ringing in the ears, restless mind, headach, etc. Test just came back 6-10igg and 0-3 IBM neg. Dr says I don't have the lymes and should look towards something else. They ran all test from head to toe and I also found out I have elevated lived enzymes and an enlarged spleen both symptoms of late term lymes...don't know what to do very frustrated.

sabrina said...

Hi there - thank you for this helpful blog. Though, it doesn't totally clear up my confusion! I was hospitalized for an optic neuritis and the only test (or part of test) that came back positive is the serology for IgM. Also, it is positive only for the blood, not for the spinal fluid (if that means anything???). I was released without even any mention of that result so I am assuming they considered it a false positive. Should I be worried and push for a western blot? I lived in NY state so I was certainly exposed to Lyme but I am living in Italy and I am not sure they are so familiar with Lyme...

Marie said...

Hi Sabrina.
They (CDC) wouldn't call your results a "false positive" they would say it is Negative. Like Lyme MD mentioned in his post to be considered positive by CDC criteria you must have at least 2 of the 3 igm and at least 5 of the 10 igg bands to be positive.
I was lucky that I met that criteria for 11 mos. (3 out of 3 and 8 out of 10 for a long time)
I'm now considered negative (by CDC criteria) after a yr. of abx. My "negative" is higher than some fellow Lymies "positive" lol. My dr isn't calling me cured we are watching and seeing. I feel better of abx this past month, my numbers are coming down, but I still have tinnitus and don't feel 100%.
The only reason I am putting some stock in my test results was that I was such a high positive on all Lyme tests incl WB, Elisa, C6 peptide, PCR live blood and PCR live urine and numbers are dropping...my index is finally 2.50 (was over 5 for a long time.)

Marie said...

Sabrina...you didn't mention how long you've had Lyme ? If you just got it that may be a reason why you only have igm antibodies, because the igg maybe haven't been produced yet.???
Thanks Lyme MD for clarifying the igm concept that the body may be reacting to an ongoing infection as if it was an early acute infection. This has me thinking because my first negative Lyme tests after 11 mos. of tx showed only 1 igg, the following mos another one reappeared after I stopped abx tx....I also got another igg band back as well during that mos (went from 1 band to 2igg) overall still hopeful considering how high my positive was.

Anonymous said...

I was bit by a tick almost 10 years ago now, I found it buried in my leg. I was diagnosed with lymes on severe clinical symptoms immediately following the bite. I was given 2 weeks of doxy. I have never felt right since that day. I have literally every symptom in the books although I have never tested positive for lyme. Until my bloodwork came back 3 days ago. I tested positive for IgM p23 but no IgG. I have been to EVERY specialist that exists in the world for a slew of symptoms only for many of them to patronize me and tell me it's anxiety, or to diagnose me with vague diseases such as autoimmune arthritis and chronic fatigue. Any idea what significance this positive IgM p23 has without another band present? Is this finally a break in the mystery that has become my body?? Any insight would be not only helpful but words can't describe how desperate I am to figure out what's wrong with me! thanks in advance!

Lyme report: Montgomery County, MD said...

The 23 band shows a reaction to a protein on the exterior of the Lyme spirochete, Osp C, Outer Surface Protein C. This protein is found only on the Lyme spirochete. If this result was for any other disease other than Lyme disease doctors would take note. Please consult with a physician knowledgeable about Lyme disease.

Unknown said...

I had Lyme in 2002 & 2010. Antibiotics were a success. Neither time did I find a tick but ticks seem to be the only way Lyme can contracted so I guess I had a tick bite. I was relatively healthy the 8 yrs in between both episodes. I just went for my yrly. physical. I feel the healthiest I've felt in the 48 years of my life (Training for a half marathon..). The dr ran a Western Blot, they are doing this automatically now as lyme is so prevalent in my area. He said it came back + bcuz IgM P23 was present (the only band present). Only IgG P23 & 18 are also present. He wants to treat me for Lyme. Why? ALso, I have psoriasis (auto imm.) can this cause IgM p23 to be present?

Unknown said...

The logical thing to do is test a patient with both the OspA nano-trap ANTIGEN test and the Igenex IgM 31 ANTIBODY test, with epitope confirmation. If they are both positive then you may have a valid theory for Igm 31 and broken immunity conversion to IgG.

Unknown said...

My 14 years old daughter is a excellent athlete and A plus student. In her blood tests her Western Blot came positive IgM P41 Ab and IgM P23 Ab came positive. We were very concerned about it because she was born in CT and lived there until 3 years ago. So, we took her to LLMD who started the treatment and she has been taking Monocyclen twice a day everyday and Flucozolane twice a week and also other supplements as well as probiotics. She was very vibrant and well before the treatment, now she feels very fatigue and sad all the time... The Doctor also found out that she has C667T homozygous (Methylation Defect) and added some supplements for it. We also took her to a Infectious Disease Doctor who did not believe that she has Chronic Lyme and instruct us to stop the treatment. Now, we went back to the LLMD who wants to add another antibiotic to her regimen. We are very concerned and scared to which approach should we take? Please, any suggestions to maybe a less invasive treatment so we can combat this virus , so our daughter would never develop Acute Lyme Disease? Please, help us to make a decision about our daughters' treatment. Thank You so much!

LymeBeGoneFriend said...

Beating back Lyme is a long process and antibiotics/ methylation supports can be very useful, and it generally takes quite some time, during which the patient does not feel great, generally worse than before starting the therapy. That said it is worth continuing the regimen and trusting your LLMD. If you feel you need a second opinion, it is best to get a Lyme competent alternative practitioner eg LLND or another LLMD, but not another health practitioner who is not very familiar with this condition.

Remember that antibiotics work but have side effects and patient needs lots of good quality spring water to flush out kidneys during the treatment. Adrenal glands generally need support with Lyme also eg. methylated vit B's, liposomal vit C and zinc.

Generally recovering from Lyme can be about a two year process !

Hope this helps !

Unknown said...

igM 23 showed and nothing else for me for 5 years of testing. Finally got treated and symptoms abated in first two weeks of antibiotics. It was certainly an active chronic infection. I'd love to see igG's show up but i'm not sure they ever will.

Cora Regina said...

I just got my test results back: IgM had 34 + (which of course the CDC ignores), 39 +, and 41 ++. IgG had 31 + (and more CDC BS), 39 IND, and 41 ++. Now looking for an LLMD, because my current holistic doctor isn't one and wants to run me through the herbal ringer and I just don't see silver and iodine helping.

PrimReaper said...

To whom would you direct me to see in North Carolina that understands the disease; as well as proper testing? Thank you.

PrimReaper said...

To whom would you direct me to see in North Carolina that understands the disease; as well as proper testing? Thank you.

The Oil Snob said...

I tested positive for IGG 41 and IGM 23,39,41 on the western blot. My husband thinks I don't have Lyme and wants me to do more testing. Which test would confirm? CD57, nanotrap antigen test, and igenex Lyme and confections are what we're are thinking about doing. Right now I am being treated for hplyori then my doc wants to start doxy and diflucan. I am waiting to get into a LLMD, hopefully soon.

Km said...

I am amazed at what i am reading !!I have been going thru the same exact thing ..my results are igm reactive 23 and nothing else so Dr's saying in negative ..have beenough to every dr under the sun and all are saying anxiety. ..in wouldn't give up cause I knew it's not anxiety ...finally a natural health dr decided ti treat me dir lymes based on my reactive blot 23 and took doxycycline fir 4 wks feel worse then ever ! My worst symptom is the dizziness I can't take it..I do have athritic pains and numbness Ringling in my hands and feet but the dizziness drives me insane I've become a compleltwly different person I want my life back !! Will I get it ...it's almost a year like this!!!

mark henry said...

I am indeed very happy for my life; I never thought that I will live on earth before the year runs out. I have been suffering from a deadly disease [HERPS] for the past 2 years now; I had spent a lot of money going from one places to another, from churches to churches, hospitals have been my every day residence. Constant checks up have been my hobby but until this faithful day, I was searching through the internet, I saw a testimony on how a spell caster helped someone in curing his HERPS disease, quickly I copied his email which is (doctorumiefanherbalcentre@gmail.com)
I spoke to him, he asked me to do some certain things which I did, he told me that he is going to cast the spell which he did, then he asked me to go for medical checkup after 45 minutes of casting the spell, I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I own him my life, if you are having a similar problem or suffering from any of these diseases such as HERPS,HIV,ALS,MND,CANCER,DIABETES just email him on (doctorumiefanherbalcentre@gmail.com) or call him on +2348134470041... I pray that God that used the great doctor umiefan to cure me will surely answer you (AMEN) I am now very happy again with my family. A word is enough for the wise..

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Unknown said...

I am going through a very similar situation and would love to talk more. Feel free to contact me at snookie4123@aol.com or crystal blumberg on facebook.

Unknown said...

I am looking for help or any feedback. I tested positive for two out of three bands Igm test and negative IGG test in 2011. Have had continued symptoms since then. In 2013 I had just a reactive band 58. 58 was not previously reactive as well as a low positive ana.In the last three years I have developed what they have finally diagnosed and psoriasis and psoriatic arthritis (because of terrible joint pain in the hands) Hearing from anone who might have any feedback at all would be so appreciated. Contact me on facebook or at snookie4123@aol.com

Unknown said...

I am looking for advice on whether to push for a lyme diagnosis or not. My trouble is, there aren't many LLMDs in my area so it will be an expensive process. After seeing so many other specialists and testing, my pocket is empty and don't want to waste any more money if it's just fibromyalgia (dx'ed in march 2017). Anyone with experience, please email me at kar25_50@msn.com
I've had two western blots with 23 and 41 igm positives both times and once with both 41 igg and 41igm antibodies. Thank you in advance!!

Linda Maran said...

I have been struggling with Lyme Disease for nearly seven years. I have had IGM and IGG bands. Mostly IGM 23 positive and IGG 41 and 47. Sometimes total negative bands but it doesn't last long.
After many courses of antibiotics for two to three weeks at a time and for one month another time, I decided to go to an Infectious Disease specialist. He tested me for Babesia, telling me I did not have Lyme Disease despite the test results. He said: "You've been treated." But I did test positive for Babesia but only in the antibodies and not in the smear test, so he said it was mild and put me on a malaria medication and Zithromax for one week. Even though I still felt sick afterwards he would not retest me. Instead I was told to go to a Rheumatologist who took every auto-immune test there is. All came out negative. He found that I have osteoporosis, which is not fun, but he too denied Lyme Disease, would not even look at my tests. He tested me with a PCR for Lyme which is a totally unreliable and it came out negative. Yet he ignored my positive band 23 I have a month or so earlier. I just had another Western Blot done last week and Band 23 IGM is positive. My doctor said it needs to be treated and prescribed Doxycycline again for two weeks. My knees hurt and I am very fatigued and I also have bad pain in my rib cage. So I guess I'll take the meds and see if I feel any better. I keep relasping. This is not a new infection because I have not gone up to my country house where I originally got bit. BUT regarding an LLMD. The one closest to me which is 1 1/2 hours, charges $800 for the consultation and $365.00 each monthly visit. Doesn't take insurance.(None of them do.) I think this is as bad as the MDs who will not treat Lyme. It weeds out folks who cannot afford treatment. So either way, we cannot get the proper care. It's really disgraceful. I am thinking after this to try what is called The Bob Beck Protocol. Using electrical and magnetic pulsing to kill bacteria in the blood with drinking some colloidal silver and lots of water to flush them out. The guy was a brilliant scientist. I wish everyone healing.

henry said...
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Unknown said...

This was a very informative and helpful article- thank you so much for taking the time to explain some of these very complicated details!

Unknown said...

I'm in the exact same situation. Been going through this for 2 year and just dx'd with Lyme. 3 bands igm reactive. No igg. I don't get it. Dr says it's a recent infection. Why have I felt bad for 2 years and not getting better.

Gary Madison said...

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diego miles said...

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Gary Madison said...

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cynthia lende said...

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Hello everyone out there, i am here to give my testimony about a herbalist called dr imoloa. i was infected with herpes simplex virus 2 in 2013, i went to many hospitals for cure but there was no solution, so i was thinking on how i can get a solution out so that my body can be okay. one day i was in the pool side browsing and thinking of where i can get a solution. i go through many website were i saw so many testimonies about dr imoloa on how he cured them. i did not believe but i decided to give him a try, i contacted him and he prepared the herpes for me which i received through DHL courier service. i took it for two weeks after then he instructed me to go for check up, after the test i was confirmed herpes negative. am so free and happy. so, if you have problem or you are infected with any disease kindly contact him on email drimolaherbalmademedicine@gmail.com. or / whatssapp --+2347081986098.
This testimony serve as an expression of my gratitude. he also have
herbal cure for, FEVER, DIARRHOEA, MOUTH ULCER, MOUTH CANCER FATIGUE, MUSCLE ACHES, LUPUS, SKIN CANCER, PENILE CANCER, BREAST CANCER, PANCREATIC CANCER, CHRONIC KIDNEY DISEASE, VAGINAL CANCER, CERVICAL CANCER, DISEASE, JOINT PAIN, POLIO DISEASE, PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, CYSTIC FIBROSIS, SCHIZOPHRENIA, CORNEAL ULCER, EPILEPSY, FETAL ALCOHOL SPECTRUM, LICHEN PLANUS, COLD SORE, SHINGLES, CANCER, HEPATITIS A, B. DIABETES 1/2, HIV/AIDS, CHRONIC PANCERATIC, CHLAMYDIA, ZIKA VIRUS, EMPHYSEMA, LOW SPERM COUNT, ENZYMA, DRY COUGH, ARTHRITIS, LEUKAEMIA, LYME DISEASE, ASTHMA, IMPOTENCE, BARENESS/INFERTILITY, WEAK ERECTION, PENIS ENLARGEMENT. AND SO ON.

Gary madison said...

My mother was diagnosed with ALS in june 2015. Her doctor put her on riluzole, letting her know there was no cure but the medication might provide her a few more months of delayed symptoms. ALS progresses at different rates and affects different body parts first. My mother, being 80 at the time, fell into a category of what they call "fast progression" (older female). Her arms weakened first, then her hands, her mouth, and throat, and finally her lungs. Throughout her years ordeal, she was able to walk with assistance. We have to give a try on herbal supplement which effectively get rid of herbal ALS condition dramatically after her 15 weeks of her usage,she lost touch with reality. Suspecting it was the medication I took her off the riluzole (with the doctor’s knowledge) and started her on the ALS natural herbal formula we ordered. it advisable to always try natural herbs at first because totalcureherbsfoundation.com neutralize her ALS/MND which surprise everyone at home.

Indah Pasik said...

Use Herpes Herbal Medicine to Cure and eradicate this Virus totally from your body system, be free from Outbreak with Natural Roots and Herbs. Dr. AKINTUNDE who restored me from Herpes Virus and my Mom who had suffered 18 years Herpes with frequent outbreak, I was diagnosed of Herpes two years ago then I thought it was the end of my life. So everyday I kept on praying and searching for solution to my health problem online. when I came in contact with Dr. AKINTUNDE, patient who he cured of this Virus and she recommended me to Dr. AKINTUNDE. I told him about my situation and all what I was going through, so he assured me that his herbal medicine will eradicate this virus from my body system in just four weeks of Using his Natural Herbal Medicine, at first I thought it was impossible to cure this Virus because I have suffered so many Outbreak. Finally Dr. AKINTUNDE prepared some Herbal Medicine which He sent to me through DHL delivery courier which I took as he directed me, so after the last week of taking my herbal medicine, I felt better and relieved, then i went back to the hospital for my test and my result was Negative, I had to go to another hospital for test again and I was also confirmed Negative and free of this virus, that is why i thanks Dr. AKINTUNDE publicly for my life and also i thank him for sending his herbal medicine to my mom too. just the herbs and roots herbal medicine that he sent to my mom and directed her on how to use the herbal medicine daily, after my mom took the herbal medicine she was also confirmed free of this virus with no symptoms again. Sir. God will reward you for being a blessing to me and my Mom. So feel free to turn your situation to Testimony if you have this. contact. Dr. AKINTUNDE on his WhatsApp for help... +12068994141

joy nelson said...

I'm here to testify about the great work Dr okosun did for me. I have been suffering from (HERPES) disease for the past 4 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from different doctors, few weeks ago i came across lots of testimonies from different people on a particular doctor on the internet called Dr okosun on how he cured various people from Herpes Simplex Virus and other diseases. i took the email address of this man from one of the testifiers advising anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to be cured! , well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr okosun assured me that i will be cured,after two week of taking his medication as told by dr okosun, i went to my doctor for herpes virus check up and behold i was declared negative, i also waited for a week and went to another hospital for another check up to be be truly sure and behold i was still declared herpes negative, And i want to use this opportunity to tell those people out there secretly suffering from herpes or other diseases should contact dr okosun and get cured. you can get in touch with this doctor via email : drokosun55@gmail.com. You can also whatsapp him +2348124363791. Thanks once again Dr okosun god bless you

RUTH MARIS said...

I am very happy to inform the general public that I am finally cured from Herpes simplex virus recently with the use of herbal medicine, the powerful herbal medicine cured me completely and i was tested negative after usage, I am using this means to inform other's who have the virus that there is a cure for Herpes simplex 1&2 . It is absolutely true. I was cured by Dr Alli, only him I can recognize who cure Herpes perfectly well. I will advice you to contact this great doctor who God has send to put an end to the sorrowful and deadly disease. Contact him via Email  Allispellhelp1@gmail.com or add him on WhatsApp +2348100772528

Amanda Bella said...

I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Look For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com

Or Cell Whatsapp Number +2348101755322 thank you .....

Unknown said...

Website lymedisease.org is a good site to find a lyme literate dr. Near you. Also Bryon White herbs is what my dr. Is using to treat my lyme.

mr job said...

i want to inform the public how i was cured of HERPES Simplex Virus by a Doctor called Dr.EBHOTA. i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Doctor EBHOTA cured them. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of HERPES so i decided to contact him on his email, i searched his email on net and i saw a lot of people testifying about his goodness. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. You can contact him on
his Email: drebhotasolution@gmail.com or whatsapp him on +2348089535482 and get all your problem solved.
1Sickness of any kind
2 Help to CURE Hepatitis B, HIV/AIDs CANCER and BIPOLAR
3 Divorce, Breakup problem and To Re-unit
4 Pregnancy problem
5 Financial problem and Job promotion
6 To get a good and rich life partner
7 To Lose your wath
8 to enlargement of pennis
9. CANCER
10. ALS (Lou Gehrig's disease)
11 Hepatitis B
12 chronic pancreatic
13 emphysema
14 COPD (chronic obstructive pulmonary disease)   

Marie Planta said...

I found out, that taking herbal treatment is the best to get rid of hpv as soon as i feel the symptoms of hpv is appearing, i took the healing process by contacting Dr Oyagu for natural treatment it works wonders, amazingly ever since I had the herbal treatment i have not feel these horrible disease anymore and my doc told me the virus is gone, i am glad i finally got cured out from this horrible disease. every hpv or herpes patients should also get in touch with this herbalist Dr to get ride of these disease forever his email address:Oyguspellcaster@gmail.com or wahtsapp +2348101755322 thank you.....

joy nelson said...


I'm here to testify about the great work Dr okosun did for me. I have been suffering from (HERPES) disease for the past 4 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from different doctors, few weeks ago i came across lots of testimonies from different people on a particular doctor on the internet called Dr okosun on how he cured various people from Herpes Simplex Virus and other diseases. i took the email address of this man from one of the testifiers advising anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to be cured! , well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr okosun assured me that i will be cured,after four week of taking his medication as told by dr okosun, i went to my doctor for herpes virus check up and behold i was declared negative, i also waited for a week and went to another hospital for another check up to be be truly sure and behold i was still declared herpes negative, And i want to use this opportunity to tell those people out there secretly suffering from herpes or other diseases should contact dr okosun and get cured. you can get in touch with this doctor via email : drokosun55@gmail.com. You can also whatsapp him +2348124363791. Thanks once again Dr okosun god bless you



joy nelson said...


I'm here to testify about the great work Dr okosun did for me. I have been suffering from (HERPES) disease for the past 4 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from different doctors, few weeks ago i came across lots of testimonies from different people on a particular doctor on the internet called Dr okosun on how he cured various people from Herpes Simplex Virus and other diseases. i took the email address of this man from one of the testifiers advising anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to be cured! , well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr okosun assured me that i will be cured,after four week of taking his medication as told by dr okosun, i went to my doctor for herpes virus check up and behold i was declared negative, i also waited for a week and went to another hospital for another check up to be be truly sure and behold i was still declared herpes negative, And i want to use this opportunity to tell those people out there secretly suffering from herpes or other diseases should contact dr okosun and get cured. you can get in touch with this doctor via email : drokosun55@gmail.com. You can also whatsapp him +2348124363791. Thanks once again Dr okosun god bless you



Success James said...

FINALLY FREE FROM HERPES VIRUS
I thought my life had nothing to offer anymore because life
became meaningless to me because I had Herpes virus, the
symptoms became very severe and bold and made my family
run from and abandoned me so they won't get infected. I gave
up everything, my hope, dreams,vision and job because the
doctor told me there's no cure. I consumed so many drugs but
they never cured me but hid the symptoms inside me making
it worse. I was doing some research online someday when I
came across testimonies of some people of how DR Ebhota
cured them from Herpes, I never believed at first and thought
it was a joke but later decided to contact him on the details
provided and when I messaged him we talked and he sent me
his herbal medicine and told me to go for a test after two
weeks. Within 7 days of medication the symptoms
disappeared and when I went for a test Lo and behold I was
NEGATIVE by the Doctor Who tested me earlier. Thank you DR
Ebhota because I forever owe you my life and I'll keep on
telling the world about you. If you are going through same
situation worry no more and contact DR Ebhota via
drebhotasolution@gmail. com or WhatsApp him via +2348089535482.
he also special on cureing 1. HIV/AIDS2. HERPES 3. CANCER 4.
ALS 5. HEPATITIS B 6.DIABETES 7. HUMAN PAPILOMA VIRUS DISEASE(HPV)8. 
ALZHEIMER 9. LUPUS (Lupus Vulgaris or LupusErythematosus 

Dana Lynn said...

I am so Happy to be writing this article in here, i am here to explore blogs forum about the wonderful and most safe cure for HERPES SIMPLEX VIRUS . I was positive to the deadly Virus called HERPES and i lost hope completely because i was rejected even by my closet friends. i searched online to know and inquire about cure for HERPES and i saw Dr ehiaguna testimony online on how he was cured so many persons from Herpes Disease. so i decided to contact the great herbalist because i know that nature has the power to heal everything. i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via FEDEX  and it got to me after 4 days! i used the medicine as he instructed me (MORNING and EVENING) and i was cured! its really like a dream but i'm so happy! that's the reason i decided to also add more comment of Him so that more people can be saved just like me! and if you need his help,contact his Email: (drehiaguna@gmail.com) you can contact him on whatsapp +2348073908953 . He also cure the below listed sickness; (1) HERPES, (2) DIABETES, (3) HIV&AIDS, (4) URINARY TRACT INFECTION, (5) HEPATITIS B, (6) IMPOTENCE, (7) BARENESS/INFERTILITY (8) DIARRHEA (9) ASTHMA...

shwan said...

I want to write a little testimony about the good work of dr ebacol who cured me from Hsv 1 and 2 for just 2 weeks with his herbal medicine, I never believe I can be normal again and have a good life like others I always regretted the day I got diagnose with the virus, I was lost of hope when my doctor told me there is no cure for it but I keep thinking and thinking about my future, if I can have kids of my own well I am so grateful for my helper who get me cured with his herbal medicine, I go online in search of anything that can help me because I can’t deal with it forever so I found this doc Ebacol email on a blog of someone who was cured by him I quickly contact him for help and explain all my pain to him, he told me not to worry about it there is cure for real, I never believe until he send me the herbal medicine when I order for it and I have it within 4 days that is how I took the medicine for 2 weeks and the following week I go for test just to confirm I was 100% cured from this sickness what a miracle in my life I am so happy right now, you can also get in contact with him if you have such sickness through email address drebacolherbalhome1@gmail.com or text him on what's app, phone number +2348159042641 Dr Ebacol also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Ebacol and be free from suffering.       

Mary Frankly said...

Good news this is to everyone out there with different health challenges, as I know there are still a lot of people suffering from different health issues and are therefore looking for solutions. I bring you Good news. There is a man called Dr ehiaguna a herbal practitioner who helped cure me from HSV (2), i had suffered from this diseases for the past 5 years and i have spent so much money trying to survive from it. I got my healing by taking the herbal medicine Dr ehiaguna sent to me to drink for about 14 days . 3 days after completion of the dosage, I went for a medical checkup and I was tested free from HSV. all thanks to God for leading me to Dr ehiaguna who was able to cure me completely from this deadly diseases, I’m sharing this so that other people can know of this great healer called Dr ehiaguna because I got to know him through elizabeth who he cured from HIV. I was made to understand that he can cure several other deadly diseases and infections. Don’t die in ignorance or silent and don’t let that illness take your life. Contact Dr ehiaguna through his email  drehiaguna@gmail.com You can also whatsapp/call him on:+2348073908953 .He cure all forms of disease {1}HIV/AIDS {2}DIABETES {3}EPILEPSY {4} BLOOD CANCER {5} HPV {6} BRAIN TUMOR {7} HEPATITIS {8}COPD{9} SICKLE AND ANAEMIA.etc Be kind enough to share as you received.  

shwan said...

Always, anywhere and anytime,I feel very comfortable now all to the work of Dr Ebacol,the Herbalist who prepare for me the remedies to my health challenges.i could feel more comfortable when he explained to me how dangerous it's caring Herpes with me getting affected easily with Other sexually transmitted infections. Genital sores increases my risk of transmitting or contracting other sexually transmitted infections, including AIDS.
Newborn infection. ...
Bladder problems. ...
Meningitis. ...
Rectal inflammation (proctitis).
I was so scared when he says that because I found a lover who ran into it and had a shock on me after the checkup and develop stroke.
This has been my earnest prayers for the physician therapist to come in with positive solutions to remedies Herpes and most viral infections. I'm now free and I thank God for leading me to see others getting cured with Herbs. I decided to try and found out that the best way I would have done was to get rid of it and give my testimony. Glory to God I became free after I received his medicine from the DHL and applied as instructed. Till date I had no SYMPTOMS nor virus to detect of me, I called him and thankful for what he did,and ask if he could cure my stroke boyfriend,he said yes and did the same preparation to my boyfriend for his stroke and Recovered from it. Nothing is impossible with Herbs IN CURES, you're the next if you will be willing to apply his medicine and instructions on how to manage.
Sickness has no right to dwell on us,you can reach him at his email address
For your immediate response to health

   drebacolherbalhome1@gmail.com  
Cell number (WhatsApp/calls)
    +2348159042641  

Raymond said...

Herpes is a serious and recurring disease which can't be cured through drugs or injections by the doctors but the best way to deal with Herpes is by taking natural herbs medicine for it,  I have read about DR NOGADU the great herbalist doctor who cure me from herpes  with his powerful herbal medicine.  i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! After 2 days of contacting him, he told me that the cure has been ready and he sent it to me via UPS SPEED POST and it got to me after 3 days! i used the medicine as he instructed me (MORNING and EVENING) and i was cured! It was really like a dream but i was  so happy! you should contact him for his herbal medicine because i am a living testimony and i was cured of herpes and his medicine is legit.  I sent him what he requested and he sent me his medicine which I took for 2 good weeks and today I am out here with a negative result. When I went for the test I was so happy after going through his medication. you can reach him through his email: drnogaduherbalist@gmail.com or call/whatsapp number:+2347010627760 he will help you out.

Clara david said...

WHAT A GREAT MIRACLE THAT I HAVE EVER SEE IN MY LIFE. My names are Clara David I’m a citizen of USA, My younger sister was sicking of breast cancer and her name is Sandra David I and my family have taking her to all kind of hospital in USA still yet no good result. I decided to search for cancer cure so that was how I found a lady called Peter Lizzy. She was testifying  to the world about the goodness of a herbal man who has the roots and herbs to cure all kinds of disease and the herbal man's email was there. So I decided to contact the herbal man @herbalist_sakura for my younger sister's help to cure her breast cancer. I contacted him and told him my problem he told me that I should not worry that my sister cancer will be cure, he told me that there is a medicine that he is going to give me that I will cook it and give it to my sister to drink for one week, so I ask how can I receive the cure that I am in USA, he told me That I will pay for the delivery service. The courier service can transport it to me so he told me the amount I will pay, so my dad paid for the delivery fee. two days later I receive the cure from the courier service so I used it as the herbal man instructed me to, before the week complete my sister cancer was healed and it was like a dream to me not knowing that it was physical I and my family were very happy about the miracle of Doctor so my dad wanted to pay him 5 million us dollars the herbal man did not accept the offer from my dad, but I don't know why he didn't accept the offer, he only say that I should tell the world about him and his miracle he perform so am now here to tell the world about him if you or your relative is having any kind of disease that you can't get from the hospital please contact dr.sakuraspellalter@gmail.com or whats app him +2348110114739  you can follow him up on Instagram @herbalist_sakura for the cure, he will help you out with the problem. And if you need more information about the doctor you can mail me davidclara223@gmail.com 

Linda Maran said...

I had Lyme at least five times and IgM 23 always positive. This December 2019 I had a positive IgM 23 positive and again this June along with IgG 41 and 66.
My primary care long time doctor ordered Doxycycline and a second opinion doctor ordered the Elisa test which came out negative so she doesn't think I need antibiotics regardless of the Western Blot IgM positives and two IgGs because she follows the CDC guidelines.
I took one Doxy pill today and an now rethinking taking more since I have been on antibiotics on and off for the past seven years and it keeps coming back. Isn't it bad for my immunity to take yet another round? My main symptom is fatigue and a general feeling of being unwell with rib cage and neck pain ongoing.
Thanks for any input.
Linda-

David Peter said...

Good news this is to everyone out there with different health challenges, as I know there are still a lot of people suffering from different health issues and are therefore looking for solutions. I bring you Good news. There is a man called Dr odion a herbal practitioner who helped cure me from HSV (2), i had suffered from this diseases for the past 5 years and i have spent so much money trying to survive from it. I got my healing by taking the herbal medicine Dr odion sent to me to drink for about 14 days . 3 days after completion of the dosage, I went for a medical checkup and I was tested free from HSV. all thanks to God for leading me to Dr odion who was able to cure me completely from this deadly diseases, I’m sharing this so that other people can know of this great healer called Dr odion because I got to know him through elizabeth who he cured from HIV. I was made to understand that he can cure several other deadly diseases and infections. Don’t die in ignorance or silent and don’t let that illness take your life. Contact Dr odion through his email drodionherbalhome12@gmial.com You can also whatsapp/call him on:+2349019421176 . He cure all forms of disease {1}HIV/AIDS {2}DIABETES {3}EPILEPSY {4} BLOOD CANCER {5} HPV {6} BRAIN TUMOR {7} HEPATITIS {8}COPD{9} SICKLE AND ANAEMIA.etc Be kind enough to share as you received

Dr patrick spelltample said...

My name is Denial Edward, I want to thank Dr. Patrick who cast a SPELL that helped my family win a court case that would have sentenced my brother for life, who was charged with murder. My family and I are totally grateful. You can also contact him if you have a similar challenge on the email: drpatrickspelltample2001@gmail.com, he also cast a spell to win the lottery, get your ex-lover back, promotion spell, luck spell, coronavirus COVID 19, hiv cure / AIDS, cancer, spell to have children, etc.

Anthony said...

Hello everyone , I want to write a little testimony about the good work of doctor Abolo who cured me from Hsv 1 and 2 for just 2 weeks with his herbal medicine, I never believe I can be normal again and have a good life like others I always regretted the day I got diagnose with the virus, I was lost of hope when my doctor told me there is no cure for it but I keep thinking and thinking about my future, if I can have kids of my own well I am so grateful for my helper who get me cured with his herbal medicine, I go online in search of anything that can help me because I can’t deal with it forever so I found this dr Abolo email on a blog of someone who was cured by him I quickly contact him for help and explain all my pain to him, he told me not to worry about it there is cure for real, I never believe until he send me the herbal medicine when I order for it and I have it within 4 days that is how I took the medicine for 2 week and the following week I go for test just to confirm I was 100% cured from this sickness what a miracle in my life I am so happy right now, you can also get in contact with him if you have such sickness through email address draboloherbalhome@gmail.com or text him on what's app, phone number +2347044725611 and he has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE.HEPATIS.E.T.C I BEG everyone to contact this powerful herbal list Dr Abolo and be free from suffering

Jennifer K Robert said...

Natural herbs have cured so many illnesses that drugs and injections can't cure. I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. I read people's testimonies online on how they were cured of Herpes, HPV HIV/AIDS & STDs, Diabetics , Gonorrhea, Hepatitis, Arthritis, Chronic pains. etc. by herbal medicine, so I decided to contact the doctor because I know nature has the power to heal anything. I was diagnosed with Herpes for the past years but Dr Chike cured me with his natural herbs and I referred my aunt and her husband to him immediately because they were both suffering from herpes but to God be the glory, they were cured too .I know it is hard to believe but I am a living testimony. There is no harm trying natural herbs. Contact Dr on Whats-App . +233502715551. text/call via: +1 (719) 629 0982 , or you can also contact through his Facebook Page @ Dr Chike Herbal Remedy.