The go to CPN doc is Charles Stratton at Vanderbilt. His protocol: Amoxil, Doxy, Zithro, Flagyl and Rifampin, INH takes 2 years. The INH is toxic to the liver. I think, based on my experience that: Amoxil, Cipro, Rifampin and Flagyl may work. I use lower doses. Titers come down and Fibro symptoms may improve. Low dose Cipro has generally been tolerated but requires close watching. Has anyone had a response to similar combinations?