tag:blogger.com,1999:blog-5694894153899281485.post3622121921258827666..comments2024-03-09T08:14:49.856-08:00Comments on LymeMD: Cipro for Lyme: Back to the futureLyme report: Montgomery County, MDhttp://www.blogger.com/profile/11035327980787631502noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-5694894153899281485.post-4609087911052158382009-06-15T13:49:56.182-07:002009-06-15T13:49:56.182-07:00I am a patient and have been Rx'd Cipro. I hav...I am a patient and have been Rx'd Cipro. I have pain widespread from neuropathy, muscles and tendons. I have had a pos Ehrlichia and Bart test, which is why my LLMd prescribed it, he says it will kill both. I think he has severely overlooked my pain issues so I will not take it. I have take it prior to my Ld diagnosis for UTi's and had great success. Now with websites and youtube 'testimonials' of permanent damage and a black box warning issued from the FDA it becomes less likely I would ever use it again. Do you have any concerns about the reported perm damage ("floxing"). Also patients on NSAIDs shouldn't take cipro according to my pharmacist. I would think with all that in mind very few should be on cipro or any quinolone. Would love a response to this post.searchingforhealthhttps://www.blogger.com/profile/05682649173869179228noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-43179058643432376472009-06-15T09:13:26.579-07:002009-06-15T09:13:26.579-07:00That's an interesting idea about lower doses o...That's an interesting idea about lower doses of antibiotics. <br /><br />I stopped several abx I used to take (Biaxin, Rifampin) because the herx or side effects were too great; I wonder if I'd be able to tolerate them at lower doses. <br /><br />Do you find that patients are ok on low doses of Cipro, i.e. not too much tendon pain, depression, side effects, die off. I might bring this up with my LLMD.<br /><br />Have you dealt with patients who are violent when herxing? Rage, losing control can be particularly bad with Bartonella. I live with my boyfriend who forbids me to herx any more while I am living here since I might accidentally throw something at him as I have done previous times; I have to wait a few weeks until I can visit my parents and herx there.<br /><br />I am taking azithromycin (500mg/day) and Plaquenil (400mg/day), and it keeps whatever I have in check, and I seem to improve every month; however I relapse quickly if I stop the abx.LGThttps://www.blogger.com/profile/13040899487879988152noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-58273927772325929242009-06-15T05:36:48.264-07:002009-06-15T05:36:48.264-07:00Qunilones can have neuror-psychiatric side effect-...Qunilones can have neuror-psychiatric side effect-unrelated to effects on Lyme disease or Bartonella. Many patients experience vertigo, insomnia and strange dreams. Even so--If a drug causes a severe dangerous Herx, then in my opinion, the targeted micro-organism shoud be treated with less potent antibiotics, to lower the load of bacteria, be they Spirochetes or other bacteria. Paitents in my expericence are better able to tolerate the more antibiotics at that point.<br /><br />I have not tried Factive yet. In my experience very low doses of Cipro can be very effective. The drug provides a range of dose levels. I typically start patient with only 250mg per day. If well tolerated I increase the dose to 250mg twice daily. If the reaction is excessive the dose can be lowered to one per day, one every other day or less frequently based on clinical response.<br /><br />I no longer use medications first which have an increased likelyhood of adverse reactions. For example, I no longer use Minocin as a first drug do to excessive phsych Heres. <br /><br />Here I will go out on a limb. This is very conjectural. I believe that subclinical Lyme infection is much more common than generally suspected.<br /><br />Quinolones penetrate various tissues much better than other antibiotics. This would include tendons. Perhaps tendon rupture is the result of a localized Herx in these structures rarely leading to tendon rupture. I tend to use them later in treatment and gradually increase the dose.<br /><br />Furthermore, I do not pulse antibiotics. I have found that continuous therapy is effective.Lyme report: Montgomery County, MDhttps://www.blogger.com/profile/11035327980787631502noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-11284443762928585132009-06-14T06:56:29.041-07:002009-06-14T06:56:29.041-07:00Going to try gemifloxacin (Factive) myself for Bar...Going to try gemifloxacin (Factive) myself for Bart+Lyme soon; benefit is that the risk of tendon rupture is lower when taking the drug only 5 days.<br /><br />Still looking for better ways to deal with brain herxes before I try Factive, as I am afraid of being arrested--people in my apartment have called the police other times that I was herxing.<br /><br />Any thoughts for decreasing the rage and combativeness? Reducing brain inflammation, better detoxification, liver support?LGThttps://www.blogger.com/profile/13040899487879988152noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-65827541797907117022009-06-12T16:34:18.581-07:002009-06-12T16:34:18.581-07:00Hello,
My name is Laura, and both my mother and y...Hello, <br />My name is Laura, and both my mother and younger sister are currently suffering from Lyme. I have several questions that i would like to ask you, can you please contact me, i would really really really appreciate it.<br />thank you so muchUnknownhttps://www.blogger.com/profile/13552863349776634905noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-48896203372953635592009-06-10T23:55:54.263-07:002009-06-10T23:55:54.263-07:00You proposed that Cipro is an effective treatment ...You proposed that Cipro is an effective treatment plan for mycoplasma infections. I'm one of the individuals that received the controversial "mycoplasma or hemobartonella" infection diagnosis from Fry laboratories. I was wondering if you suggest that I should propose Cipro in conjunction with current antibiotics to Dr Fry. Also, I have not been diagnosed with Lymes but wondered if you have made any posts strictly pertaining to mycoplasma infections and information about the condition(s). I have read your post concerning hemobartonella.huffgarrhttps://www.blogger.com/profile/00973875389693722541noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-80796707108757950102009-06-10T23:48:33.534-07:002009-06-10T23:48:33.534-07:00This comment has been removed by the author.huffgarrhttps://www.blogger.com/profile/00973875389693722541noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-24674183825853836222009-06-10T12:49:36.868-07:002009-06-10T12:49:36.868-07:00Antimicrob Agents Chemother. 2001 Sep;45(9):2486-9...Antimicrob Agents Chemother. 2001 Sep;45(9):2486-94.<br /><br /> <b>In vitro activities of fluoroquinolones against the spirochete Borrelia burgdorferi.</b><br /> Kraiczy P, Weigand J, Wichelhaus TA, Heisig P, Backes H, Schäfer V, Acker G, Brade V, Hunfeld KP.<br /><br /> Institute of Medical Microbiology, University Hospital of Frankfurt, D-60596 Frankfurt/Main, Germany.<br /><br /> Little is known to date about the in vitro activity of fluoroquinolones against Borrelia species. Our study aimed at determining the in vitro activities of 15 quinolones against nine isolates of the Borrelia burgdorferi sensu lato complex in addition to one Borrelia valaisiana and one Borrelia bissettii tick isolate. For the determination of MICs, a standardized colorimetric microdilution method was applied. Determination of minimal borreliacidal concentrations providing 100% killing of the final inoculum (MBCs) after 72 h and time-kill experiments were performed by conventional culture in Barbour-Stoenner-Kelly medium in combination with dark-field microscopy. <b>The rank order of potency on a microgram-per-milliliter basis for the substances with in vitro activity against B. burgdorferi was gemifloxacin (MIC at which 90% of the isolates tested are inhibited [MIC(90)], 0.12 microg/ml)</b> > sitafloxacin (MIC(90), 0.5 microg/ml), grepafloxacin (MIC(90), 0.5 microg/ml) > gatifloxacin (MIC(90), 1 microg/ml), sparfloxacin (MIC(90), 1 microg/ml), trovafloxacin (MIC(90), 1 microg/ml) > moxifloxacin (MIC(90), 2 microg/ml), ciprofloxacin (MIC(90), 2 microg/ml) > levofloxacin (MIC(90), 4 microg/ml) > ofloxacin (MIC(90), 8 microg/ml), norfloxacin (MIC(90), 8 microg/ml) > fleroxacin (MIC(90), >16 microg/ml), and pefloxacin (MIC(90), 32 microg/ml) > nalidixic acid (MIC(90), 256 microg/ml). <b>After 72 h of exposure, gemifloxacin was borreliacidal (100% killing) against the isolates investigated at a median MBC of 4 microg/ml. In the other compounds tested, median MBCs were higher (> or =8 microg/ml).</b> Results of electron microscopy and time-kill studies clearly support an in vitro activity of some fluoroquinolones against borreliae. Our study demonstrates for the first time the enhanced in vitro effectiveness of some of the recently introduced 4-quinolones against B. burgdorferi.<br /><br /> PMID: 11502519Shawn B.https://www.blogger.com/profile/02777257378045622573noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-834260098243513892009-06-10T11:43:36.045-07:002009-06-10T11:43:36.045-07:00Actually I've heard that Dr. Horowitz is seein...Actually I've heard that Dr. Horowitz is seeing great success with gemifloxacin (Factive) and giving it to many of his patients now in a 5-day pulse fashion, either once or twice monthly. This drug has a lower MIC value than cipro for Bb and may be more effective.Shawn B.https://www.blogger.com/profile/02777257378045622573noreply@blogger.com