tag:blogger.com,1999:blog-5694894153899281485.post3483660461299873216..comments2024-03-09T08:14:49.856-08:00Comments on LymeMD: Two patients: CDC positiveLyme report: Montgomery County, MDhttp://www.blogger.com/profile/11035327980787631502noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-5694894153899281485.post-44528829019124714982009-01-19T14:19:00.000-08:002009-01-19T14:19:00.000-08:00J Clin Invest. 1986 Oct;78(4):934-9. Antigens o...J Clin Invest. 1986 Oct;78(4):934-9.<BR/><BR/> Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.<BR/><BR/> Craft JE, Fischer DK, Shimamoto GT, Steere AC.<BR/><BR/> Using immunoblots, we identified proteins of Borrelia burgdorferi bound by IgM and IgG antibodies during Lyme disease. In 12 patients with early disease alone, both the IgM and IgG responses were restricted primarily to a 41-kD antigen. This limited response disappeared within several months. <BR/><BR/>In contrast, among six patients with prolonged illness, the IgM response to the 41-kD protein sometimes persisted for months to years, and late in the illness during arthritis, a new IgM response sometimes developed to a 34-kD component of the organism. <BR/><BR/>The IgG response in these patients appeared in a characteristic sequential pattern over months to years to as many as 11 spirochetal antigens. The appearance of a new IgM response and the expansion of the IgG response late in the illness, and the lack of such responses in patients with early disease alone, suggest that B. burgdorferi remains alive throughout the illness.<BR/><BR/> PMID: 3531237 [PubMed - indexed for MEDLINE]<BR/><BR/>free full text here:<BR/><BR/>http://tinyurl.com/7o9xyflymiehttps://www.blogger.com/profile/00123316749536517739noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-45327511724076819652009-01-12T21:00:00.000-08:002009-01-12T21:00:00.000-08:00Hey- Lymemd blog readers- I just realized, we shou...Hey- Lymemd blog readers- I just realized, we should post this one on Facebook in the 'networked blogs' module (it's an app you have to subscribe to, but Networked Blogs should get really wide readership):<BR/><BR/>If you're on Facebook, go sign in as a reader of LymeMD here, it'll get the blog shown to a lot more people:<BR/>(Facebook will make you install the NetworkedBlogs app to do this)<BR/><BR/>http://apps.facebook.com/blognetworks/blog/lymemd/girl markhttps://www.blogger.com/profile/01462557261989174156noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-35347405667142817682009-01-12T20:52:00.000-08:002009-01-12T20:52:00.000-08:00you're making me cry. Again. This is so insane. An...you're making me cry. Again. This is so insane. And those are such common stories. And those are just two patients who've lucked out and found someone who'll treat them. How many more won't?girl markhttps://www.blogger.com/profile/01462557261989174156noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-52619044929665275152009-01-12T19:51:00.000-08:002009-01-12T19:51:00.000-08:00The CDC allowing for IgG positive WBs is very help...The CDC allowing for IgG positive WBs is very helpful- NOT. Lyme is an IgM disease. Less than 10% of CDC positives meet the IgG criteria.Lyme report: Montgomery County, MDhttps://www.blogger.com/profile/11035327980787631502noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-53362130344662842732009-01-12T14:18:00.000-08:002009-01-12T14:18:00.000-08:00It's such a shame what everyone with this disease ...It's such a shame what everyone with this disease is going through.<BR/><BR/>Our LLMD is in NY, he cannot even order testing from Clongen b/c it's not approved through the state Health Dept. We had to ask a doctor friend in CT to order the testing for my daughter from Clongen Labs.<BR/><BR/>If the CDC/NY State Health Dept. COULD shut down IgeneX (and the like) they WOULD. Obviously, IgeneX has been around a long, long time... they can't find a legit reason to close them. Hopefully the same will hold true for Clongen.Unknownhttps://www.blogger.com/profile/03692808539833529148noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-29266156506086491622009-01-12T13:43:00.000-08:002009-01-12T13:43:00.000-08:00Why is NY asking for an ELISA first? The CDC rece...Why is NY asking for an ELISA first? The CDC recently changed its surveillance criteria so that the two step process (ELISA first, then WB) has been changed so that only a WB is needed as the only confirmation. Does NY not know this?<BR/><BR/>The hitch is that it has to be IgG positive, for some reason. Not IgM positive.<BR/><BR/>See new case definition here:<BR/><BR/>http://www.cdc.gov/ncphi/disss/nndss/casedef/lyme_disease_2008.htmlymiehttps://www.blogger.com/profile/00123316749536517739noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-80920418516715731152009-01-12T12:12:00.000-08:002009-01-12T12:12:00.000-08:00I just don't understand. I guess a lot more of us ...I just don't understand. I guess a lot more of us need to die to have this disease taken seriously.Michelehttps://www.blogger.com/profile/12480332174441696856noreply@blogger.comtag:blogger.com,1999:blog-5694894153899281485.post-69082215228078320562009-01-12T11:06:00.000-08:002009-01-12T11:06:00.000-08:00I am so glad you are posting all these cases. This...I am so glad you are posting all these cases. This is the most important thing you can do for us all, in a way. Case after case after case.jenbooks13https://www.blogger.com/profile/16782454058786511731noreply@blogger.com